ncRNA name | mmu-miR-132 |
ncRNA Category | miRNA |
Disease name | herpes simplex virus keratitis |
Species | Mus musculus |
Tissues/Cell_line | corneas |
Methods | flow cytometry, qPCR, Western blot, viral plaque assay |
Expression pattern | up-regulated |
Functional description | miR-132 expression was up-regulated (10- to 20-fold) after ocular infection with HSV, an event that involved the production of both VEGF-A and IL-17. In vivo silencing of miR-132 by the provision of anti-miR-132 (antagomiR-132) nanoparticles to HSV-infected mice led to reduced corneal neovascularization and diminished SK lesions. |
PubMed ID | 22659469 |
Year | 2012 |
Title | Role of miR-132 in angiogenesis after ocular infection with herpes simplex virus. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.